| Phone: | +49-3641-9-49630 |
|---|---|
| Fax: | +49-3641-9-49632 |
| E-Mail: | michael.ristow@mristow.org |
Michael Ristow (Group Leader)
Long-standing expertise in establishing and characterising the role of mitochondrial metabolism as a cause of ageing and ageing-associated diseases by employing tissue-culture-models as well as genetically modified mice (M. musculus) and nematodes (C. elegans). Establishment of several links of mitochondrial metabolism and altered glucose metabolism, including diabetes mellitus, obesity and cancer. Establishment of a crucial role of mitochondrial energy conversion rates in the control of C. elegans lifespan and of a fundamentally new mechanism to explain the lifespan-extending propensities of caloric restriction, cumulating in the novel concept of mitohormesis according to which a transient increase in reactive oxygen species (ROS) formation causes a secondary and lifespan-extending increase in ROS-defense capacities of the affected organism.
For more information look at the Mitohormesis Group page of the Friedrich Schiller University (FSU).
Ristow M, Zarse K:
How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis).
Exp Gerontol.
2010;
45:410-8.
Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher M:
Antioxidants prevent health-promoting effects of physical exercise in humans.
Proc Natl Acad Sci U S A.
2010;
106:8665-70.
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M:
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.
Cell Metab.
2007;
6:280-93.
Zarse K, Schulz TJ, Birringer M, Ristow M:
Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia.
FASEB J.
2007;
21:1271-5.
Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M:
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span, and tumor growth in mice.
Hum Mol Genet.
2005;
14:3857-64.